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Also, Pasculli and colleagues suggested that therapies targeting KOA, including those addressing BMLs, produce improvements in pain and function, supporting biological basis for cell-based approaches [37]

B12 is an essential nutrient, and its deficiency is common, especially among individuals following restricted diets like vegetarianism or veganism, pregnant or breastfeeding women, older adults, those who have undergone gastrointestinal surgery or have gastrointestinal disorders, and people with an autoimmune condition known as pernicious anaemia

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